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Sleeping Beauty and the Candidate Cancer Gene Database (CCGD)

The Sleeping Beauty DNA transposon was created by Zoltan Ivics and Zsuzsanna Izsvak while working as post-doc's in Perry Hackett's lab at the University of Minnesota.  Their research was published in Cell in 1997.  The following Flash Movie is a graphic animation of Sleeping Beauty as it cuts a sequence of DNA (the transposon) from the genome and pastes it into a new location in the genome.

 

We have compiled a database of published studies that have used Sleeping Beauty as a mutagen in forward genetic screens for cancer genes. You can access the Candidate Cancer Gene Database (CCGD) here.


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